Resveratrol reviews | Advice on buying resveratrol

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Jun/09

26

How Resveratrol Packs Red Wine With Health




Resveratrol has recently attracted great interest in connection with the the so-called “French Paradox” which has long puzzled medical science. As a polyphenol type flavonoid it is in any case a very useful anti-oxidant, but many now believe it also to be the explanation of the relatively low rates of cardiovascular disease enjoyed in France despite a national diet traditionally rich in cholesterol and saturated fat. The French, of course, are also known as high per capita consumers of alcohol, particularly in the form of red wine. Recent research appears to have established that the consumption of alcohol in moderation offers significant protection for the cardiovascular system, and may even reduce the incidence of related diseases by as much as 30%. There is good evidence, however, that the resveratrol which is almost unique to red wine may provide benefits which go far beyond those which can be explained by the effects of the alcohol alone

This is not surprising in so far as fat-soluble anti-oxidants are known to be important protectors of the circulatory system against damaging attack from free radicals, and the resveratrol and other polyphenols found in red wine are likely to be highly beneficial in this context. Laboratory research, moreover, has revealed significant anti-inflammatory and blood anti-coagulant effects arising from the action of resveratrol.

But there’s still more to resveratrol than this. It’s known that some potentially harmful compounds in the body do not become carcinogenic unless and until they are metabolised by particular enzymes. Resveratrol has been shown in some laboratory research to help inhibit the activity of these enzymes and it seems possible that resveratrol may therefore have some protective effect against certain cancers. Resveratrol has also been shown in the laboratory to slow the proliferation of DNA damaged cells, which have the potential to become cancerous, and to allow time for the repair or removal of DNA damaged cells before rapid and harmful proliferation can occur. Invasive cancer tumours depend on specialised enzymes to allow them to take over healthy tissue and also need to establish their own blood supply if they are to develop. Resveratrol has been found in the laboratory to have inhibiting effects on both these processes, perhaps principally because of its anti-inflammatory qualities.

Orthodox opinion, however, currently maintains that more large scale trials are required outside the laboratory before any protective effects of resveratrol against cancer can be definitively established.

But the anti-inflammatory properties of resveratrol may also have a significant protective effect in the battle against atherosclerosis (hardening of the arteries), a significant precursor of serious cardiovascular disease. Resveratrol has also been shown to play an important role in preventing the formation of the blood clots which if they obstruct a coronary or cerebral artery may lead to a heart attack or stroke, two of the leading causes of premature death or disability in the affluent Western world.

And amazingly enough it appears that resveratrol may also have a more direct effect in terms of increasing longevity. A good deal of research has shown that reduced calorie intake may increase lifespans, including those of certain mammalian species, apparently by increasing the activity of specific enzymes. Resveratrol has also been shown to stimulate these enzymes and to enhance the life spans of worms and fruit flies. It is not known whether these findings would be replicated in higher life forms, humans included, but there seems no logical reason why they should not.

To obtain a significant intake of this potentially highly beneficial compound from wine you need to concentrate on red wine, because only this is produced by a pulp fermentation including the red or black grape skins where most of the resveratrol is found. As a rule of thumb, the richer and darker the colour of the wine, the longer the pulp fermentation will have lasted, and the more resveratrol and other polyphenols the wine will contain. Generally speaking it is those produced in the sunnier latitudes which will have the highest concentration.

No toxicity issues have been reported from the intake of resveratrol, as such, although problems of course may arise if red wine is used to excess to achieve a desired high intake. Supplements of resveratrol providing up to 50 mg are now readily available, however; whilst moderate consumption of alcohol is now generally recognised as potential boon to health, and to be particularly protective of the cardiovascular system. So there seems to be every reason to continue to enjoy a couple of glasses of wine of an evening. And your enjoyment can only be increased by the awareness that the resveratrol it contains may well be doing your health a power of good.



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Jun/09

9

Does Resveratrol Extend Ones Lifespan?




Resveratrol is a phytonutrient molecule whose time has come. It is a polyphenolic phytoalexin present in grape skins and red wine that has been shown to have antioxidant and anti-inflammatory properties. Resveratrol has potent antioxidant and anti-tumorigenic activities as well as important protective effects on the nervous system and more.

This component of red wine has been found to inhibit the proliferation of a variety of human cancer cell lines, including those from breast, prostate, stomach, colon, pancreatic, and thyroid cancers. More recently, reports on the potential for resveratrol to inhibit the development of cancer and extend lifespan in cell culture and animal models have continued to generate scientific interest.

Clinical trials are currently underway to address this question and to also determine whether resveratrol might be beneficial in cancer treatment. There is an extensive and growing amount of work devoted to the possible links between diet and a reduction in the risk of ****** cancer as well as other forms of cancer. Recently, reports have come in that resveratrol could inhibit a number of cellular events associated with the initiation, promotion, and progression of cancer.

Researchers at the Harvard Medical School and the National Institute on Aging report that a natural substance found in red wine, known as resveratrol, offsets the bad effects of a high-calorie diet in mice and significantly extends their lifespan. Research at the Northeastern Ohio Universities College of Medicine and Ohio State University indicates that resveratrol has direct inhibitory action on cardiac fibroblasts and may inhibit the progression of cardiac fibrosis. Furthermore, researchers discovered that the liver and other systems in obese mice remained healthy (when they should not have) and fat related deaths dropped thirty one percent for those mice given a resveratrol supplement.

Research by Harvard Medical School Professor of Pathology David Sinclair, MD has shown that resveratrol extends the life span of mice by up to twenty four percent and the life span of other animals by as much as fifty nine percent. Another way this research differs from earlier work is that it looks specifically at the expression of genes known to be affected by aging in several important tissue types. The group explored the influence of the agent on heart, muscle and brain by looking for changes in gene expression in those tissues.

Insulin and glucose levels in mice on the high fat plus resveratrol diet were closer to the mice on standard diet than to the mice on the high fat diet. Resveratrol again demonstrated changes associated with longer lifespan, including increased insulin sensitivity, reduced insulin like growth factor-1 levels, increased AMP activated protein kinase and peroxisome proliferator activated receptor-gamma coactivator 1alpha activity, increased mitochondrial number, and improved motor function. But, in contrast resveratrol treatment had no significant effect on body weight, serum cholesterol, radial bone growth, epithelial cell height, or messenger RNA levels for insulin-like growth factor I.

Resveratrol supplements on the market today may contain anywhere from 10 to 150 mg of resveratrol per pill, but the effective doses for chronic disease prevention in humans are not known. Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been only a few controlled clinical trials to date. However since there aren’t studies in humans, it’s impossible to say how much resveratrol is needed to create health benefits.

The amount of resveratrol in food varies greatly. Of course, understanding exactly how procyanidins work in the human body remains to be investigated, and the researchers plan to dose people with the compound in a future clinical trial. Resveratrol is a good antioxidant in any potency to help reduce oxidative stress, improving the immune system, cardiovascular system, and all other parts of the body that benefit from antioxidants.



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Chemically, Resveratrol is a polyphenol that includes the flavanoids and proanthocyanadins, both very powerful antioxidants. These are very useful for the destruction of free radicals that threaten your health and well-being in this age of excessive pollution and vehicle emissions, and also excessive exposure to the harmful factors of sunlight through the erosion of the ozone layer that acts as a filter against these harmful free radical-inducing rays.

Biohemically it is a phytoalexin, a chemical used by a plant to protect against and destroy invaders. Each phytoalexin is specific to a particular invader, whether it is an insect, a bacterium or a fungus. They can take the form of terpenes, alkaloids or any other chemical that disrupt the cell walls of or otherwise destroy the enemy to the plant concerned.

Resveratrol is particularly well known for existing on the skins of red grapes, but can also be produced synthetically and marketed as a nutritional supplement. The so-called ‘French Paradox’ relates to the low incidence of coronary heart disease in Southern France in spite of the high saturated fat content of their diet. At least part of this is claimed to be due to the Resveratrol content of the red wine they drink, although the quantity even in a whole bottle is very small.

However, before considering the nutritional benefits of the extract, apart from red grape skins where else can resveratrol be found? Japanese knotweed is a bushy perennial plant, about 4 to 10 feet high, is a very rich source of resveratrol, and is the more important natural source of the two. Red grape skins hardly contain enough to be worthy of extracting. It is also present in minor quantities in pine nuts, peanuts and various other vines and grapes.

It has been under study for many years now for its effect on the heart and other parts of the body, and the antioxidant effect of resveratrol has been found to be unique. The effect of free radicals on the arteries is to help, along with cholesterol, to promote the thickening and hardening of the artery walls. Damage to the arteries by free radicals, and the resulting scar tissue, causes the production of even more free radicals and a vicious circle of damage and even more free radical production occurs.

The antioxidant action of resveratrol is in the enhancement of the nitric oxide content of the blood. Free radicals can reduce the levels of blood nitric oxide that in turn increases blood pressure. An increase in nitric oxide by appropriate antioxidants can help to reduce blood pressure closer to normal. Resveratrol is more effective in achieving this than any of the vitamin antioxidants, A, C or E. It does so by opening up the arteries and reducing the resistance to blood flow through them. .

It also helps to prevent blood cells from sticking together and forming clots that can lead to serious cardiovascular problems, and has been found by Canadian studies to be effective against a much wider range of chemicals that promote blood clotting than any other anti-clotting components of wine. In fact it has now been established, and more or less confirmed by the medical profession, that drinking red wine significantly reduces the effects of cardiovascular disease and can even go a long way towards curing it. Napa Valley here we come!

Inflammation is a condition that is caused by the immune system of the body, the purpose of which is to protect us against foreign invaders. However, once inflammation starts, it triggers even further immune responses itself, that if not controlled can lead to extremely painful and sometimes very serious conditions, even after the major trigger for the initial immune response has been dealt with.

Inflammation is regulated by chemicals known as cytokines, the master of which is NF Kappa B that controls all other cytokines. NF Kapa B also controls the activity of cyclo-oxygenase-2 (COX-2) essential for that part of the immune system that causes inflammation.

COX-2 is an enzyme that increases the production of Postaglandin E-2 (PGE-2) that is an essential trigger for T-cells that attack perceived foreign cells. If PGE-2 is suppressed, then the T-cells will not be activated. This is an essential part of reducing unwanted inflammation. However, it can be dangerous to suppress molecules below NF Kappa B such as COX-2 or PGE-2. VIOXX is a prime example of the type of heart problems that can occur if you try that type of inhibition, and Celebrex is another.

The beauty of resveratrol is that, although advertised and claimed to control COX-2 and Prostoglandin E-2, it does so by suppressing the action of NF Kapa B, the ‘supreme controller’ of the inflammatory war.

Finally, there is also some evidence that resveratrol can have an effect on aging. It is well known that powerful anti-oxidants can help to protect against the cell destruction that free radicals can cause, and so help to protect the body against the aging effect of this cell destruction. However, there is another way in which resveratrol might contribute to us all looking more youthful in future (though for many of us it is a bit too late!).

Sirtuins (silent information regulator proteins) are enzymes that are known to promote the survival of cells through adverse conditions, such as SIRT 1 that protects against premature aging by suppressing the destruction of damaged cells long enough for them to be repaired. Plant polyphenols such as resveratrol are though to be able to activate sirtuins with the possibility of lengthening life by slowing natural cell destruction, and have also been shown to be able to slow aging by activating sirtuins to mimic the benefits of calorie restriction.

There is still a lot of research and work required on resveratrol, but the signs are evident that this is a possibility in the future for extending the average lifespan of human beings by a significant amount. In the case of yeast it has been demonstrated to be as much as 80%.

Translated to you or I that would mean us living to about 140 years old – if we want it!



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It has long been somewhat of a mystery as to why the French could eat a high fat, high calorie diet and have a lower incidence of heart disease and live long healthy lives. It was known that wine had something to do with it but over the last couple of years, compliments of Dr Sinclair of the Harvard Medical Center and Rafael De Cabo Phd., they may have isolated the properties that answer the mystery.

The key is resveratrol in the fermented skins of the red wine grape, especially grapes that come from cooler climates.

There have been published papers on the fact that people (or animals for that matter) who have calorie restricted diets live longer.

Resveratrol does many things for the body including fooling the body into thinking it is calorie restricted. Hence, the French eating high calorie, high fat diets (with wine) may live longer with less incidence of heart disease.

Here is some interesting information on various studies on resveratrol and the promising results.

- According to a study done by the Dept. of Science and Technology at the Ohio State University in 1997, resveratrol was able at a cellular level to inhibit cancer cells from dividing. It also demonstrated that the estrogenic activity was able to prevent post-menopausal bone loss.

- The Dept of Microbiology-Immunology NE Ohio University, College of Medicine, successfully treated hairless mice that had herpes lesions. Repeated tests with topical resveratrol had the same results. In the same year it was also discovered that topical reseveratrol reduced skin cancer by as much as 98%.

- In Nov. of 2006, Dr Sinclair and Rafael De Cabo, did a study on middle aged mice and the findings were extremely encouraging. The mice were divided into 3 groups; the 1st group was given a standard diet., the 2nd group a high fat, high calorie diet, and the 3rd group a high fat, high calorie diet with resveratrol. The 2nd group of high fat, high calories soon developed symptoms of heart disease and diabetes and shortened lifespan. The 3rd group with high fat, high calories and resveratrol had no symptoms of heart disease or diabetes and they were much more active than the second group even later in life. The third group of mice also lived up to 30% longer. (The standard diet mice faired as well as the 3rd group)

- In another study in April of 2008, patients who were treated with resveratrol before receiving radiation treatments, found that pancreatic cancer cells would die off during radiation sessions. This is very encouraging because pancreatic cancer can be very difficult to treat.

- Now, very interesting, what does resveratrol have in common with Viagra? They both open restricted blood flow. Viagra is limited to small blood vessels but reseveratrol opens both small blood vessels and main arteries. The circulation benefits of resveratrol may outperform Viagra.

- The reasoning behind resevratrol being hailed as the potential fountain of youth is because taking resveratrol regularly has been demonstrated to reduce and or reverse DNA mishaps. Aging comes about when cells can no longer replicate cell DNA and thus begins the gradual decline of the body. Resveratrol stimulates what is called the longevity gene (caloric restricted diets) and it has been demonstrated that resveratrol reduces DNA mishaps by as much as a whopping 60%! Even if it was 30% that would be impressive!

There is still much studying to be done on resveratrol, especially on humans but the research so far has been more than promising. A glass of wine a day can be beneficial but good quality, pure resveratrol supplements have the potential for great health benefits!



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Resveratrol is a polyphenol type flavonoid currently exciting great interest as a potential boon to health. Like other flavonoids and polyphenols, it is a very useful anti-oxidant in its own right, but resveratrol has attracted particular attention as a potential solution to the so-called “French Paradox”.

This is the term used to describe the phenomenon, which has long been a puzzle to medical science, by which rates of cardiovascular disease in France have remained low relative to those in the rest of the developed world, despite the widespread national consumption of a diet high in animal fat and cholesterol, and a firmly entrenched tobacco habit. Of course France also enjoys many of the benefits of the so-called Mediterranean diet through its high intake of fresh fruit and vegetables, oily fish and olive oil, but there are good reasons to think that the consumption of red wine may be the real explanation of the apparent paradox.

It is known in any case that the moderate consumption of alcohol has a significant protective effect on the cardiovascular system, reducing disease by as much as 20-30%, but conventional medical opinion is characteristically cautious in acknowledging that the resveratrol in red wine may have any benefits over and above those which would in any case be provided by the alcohol. However, the role of fat-soluble anti-oxidants in protecting the circulatory system from damaging free radical attack is well understood, and it would therefore appear that the resveratrol and other polyphenols contained in red wine can only be beneficial. Laboratory tests, moreover, have shown resveratrol to have significant anti-coagulant and anti-inflammatory effects.

For the purposes of obtaining your intake of resveratrol from wine you need to know that it’s contained principally in the skins of red or black grapes, and is consequently found in significant quantities only in those wines produced by an initial pulp fermentation which allows the developing alcohol to leach both colour and other substances, including resveratrol, from the skins. It follows that the longer this pulp fermentation is allowed to continue the more resveratrol the wine will contain. So the colour of the wine is a handy guide. Generally, the richer and darker the colour of the wine the more resveratrol will be found. Rose types and light reds may contain some, but white wines produced by a juice fermentation alone will provide little if any.

Usually it is the red wines produced in the sunnnier climates close to the Mediterranean, and the New World, which will be richest in resveratrol, and dark red wines of this type may provide as much as 2 mg of resveratrol in a small 5 oz glass. But unfortunately from a health point of view, these also tend to be the strongest in alcohol and the so-called “congeners” which accentuate hangovers.

But fortunately for those who dislike red wine, or are concerned about alcohol intake, other sources of resveratrol are available. The amount in foods varies widely, but the best sources are peanuts and red grapes, both of which may provide anywhere between 0.3 and 1.3 mg of resveratrol per cup. Bilberries and cranberries may also be a useful source.

Supplements of resveratrol are also now readily available, principally in the form of red wine or red grape extracts, which will also contain other anti-oxidant polyphenols. Manufacturers’ recommended doses will typically provide between 10 and 50 mg of resveratrol, which would require a very high, and potentially hazardous, level of wine consumption to achieve regularly.

That said, there is no known toxicity from taking resveratrol, as such, although its blood thinning properties will tend to inhibit the blood’s clotting ability and resveratrol is therefore not recommended for those taking anti-coagulant drugs such as warfarin, or certain types of anti-inflammatory including aspirin. Needless to say, however, toxicity problems of a different kind may occur if alcoholic drinks are used to excess as the principal or only source.

But as noted above, moderate consumption is generally recognised to be beneficial to health, particularly for the cardiovascular system. So the message seems to be: if you want to enjoy a couple of glasses of wine with your dinner then go right ahead. And have that age old pleasure enhanced by the knowledge that the resveratrol it contains is also doing you some good.



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Resveratrol is a chemical that is found naturally on the skin of red grapes, of the polyphenol family that includes such other members as the powerful antioxidants anthocyanadin and the flavanoids. They destroy free radicals that are responsible for many ill effects in the body, including cardiovascular disease and aging. Aging occurs through the destruction of body cells that free radicals initiate, and can theoretically be retarded by the destruction of the free radicals.

Free radicals are becoming more common invaders of our bodies due to their increasing concentration in the atmosphere through vehicle and aircraft emissions, and also of our seas and rivers through industrial effluents. Free radicals are also created by excessive radiation, such as the harmful UV content of sunlight that is no longer effectively filtered by an adequate ozone layer.

Resveratrol is known to be effective against cardiovascular diseases due to its anti oxidant properties, and also for other reasons, but it is also believed to be a possible anti-aging supplement, to beat off the effects of old age. There is the obvious reason of it being a very powerful anti-oxidant and so preventing cell damage through the effects of free radicals, but there is more to it than just that.

The French do not seem to possess a longevity beyond that which could be expected from their diet high in saturated fats and alcohol. The fact that most of that alcohol is in the form of wines, especially red wines, is significant, but their high cheese intake with its cholesterol and saturated fat content, and other highly saturated animal fats, would be expected to cause a much lower average life expectancy that that which is actually normal in the area.

Although resveratrol is commonly found on red grape skins, and is a constituent of red wine, the quantities are small and it is the Japanese Knotweed that is the major natural source. Resveratrol is currently manufactured from knotweed, which is the main source of the supplement in health food stores. In fact you can purchase online what is described as ‘>99% pure knotweed Resveratrol that is not contaminated with plant residues.’ A lot depends on your viewpoint I suppose!

Perhaps the biggest contribution to be made to longevity by resveratrol is that it can activate the SIRT1 gene. This is the gene that activates the protein and enzyme sirtuin. Sirtuin is thought to be what is loosely terms a ‘protector of cells’ and helps cells to repair themselves when they are close to destruction. When the cell is not sure whether to carry on with the struggle or just give up and die, sirtuin persuades it to fight on and to repair itself. Without the sirtuin, the cell would have died, and as cells die, one ages.

However, the amount of resveratrol found in red wine is insufficient to activate the SIRT1 gene that has to be active before the sirtuin is activated, and supplementation is generally needed. The SIRT1 gene is also activated by a calorie reduced diet, and this can also help to protect cells from dying under stress. Such diets are useful in some situations, but will not necessarily prolong life for those that adopt it.

The SIRT1 enzyme is also thought by some to increase the activity of the mitochondria, the power packs inside cells that provide them with energy by processing fats. Mice fed with resveratrol appeared full of energy that was consistent with a surge in the number and efficiency of the mitochondria within their body cells. This is supported by an increase in muscle tissue. If this is true, and studies on this are continuing, then resveratrol fed to humans could also increase their energy as they age, since the aging process coincides with a reduction in the number and efficiency of the mitochondria within the cells.

This could also tie up in a way with the calorie controlled diet, since an increase in the metabolism that comes with increased mitochondria activity results in a higher calorie uptake, and so a reduction in the free calories available in the body. However, one of the mysteries of the human body is that what makes logical sense does not necessarily work in fact, and so the jury will remain out until the results of the large number of studies underway have been published.

For example, more evidence is required to prove the mitochondria activity theory unequivocally although all of the evidence so far tends to support it. At the moment resveratrol has restricted known uses, though the evidence is being collected and accumulated to provide support for the theories that exist on its ability to help us live longer and with more energy.

As more studies are carried out over the next few years, it seems highly likely that many more beneficial effects will be discovered, and those we are aware of confirmed by scientific proof. Resveratrol has many medicinal properties in addition to its beneficial effect on aging, such as its antioxidant properties, and ability to destroy free radicals, its anti-inflammatory properties where it is of benefit in the treatment of conditions such as arthritis and other inflammatory conditions, and also its effect as an antiseptic agent.

It is already known to increase the longevity of fruit flies, yeasts and worms and results on mice are just as encouraging. The theory behind its effect on human longevity is valid science, and it is known that if cells have a longer time to repair broken DNA, then they are able to do so. The enzyme sirtuin does this, and that is activated by the SIRT1 gene that is turn is activated by resveratrol. So the theory works, and so far laboratory tests are supporting this theory.

Whether or not resveratrol helps us to live longer or look younger as we age is not yet known, but studies are under way. Since the material is natural and not a prescription drug, there is nothing to prevent you from using it, but you are advised to consult your doctor before trying out medication that you have not taken before.



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  • Tell me the websites to know about the resveratrol supplements? April 23, 2013
    Sugumaran asked: Can anyone tell me the websites where I can get the details about the resveratrol .. And also mention which red wine contains more resveratrol… resveratrolThe post Tell me the websites to know about the resveratrol supplements? appeared first on Resveratrol reviews.
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